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Metabolic pathway in vivo
Biochemical metabolism in vivo
Intracellular biochemical metabolism
NutriBuilder? (Guanidinoacetic acid, GAA) is a high-tech green and efficient feed supplement, manufactured and developed by Beijing Gendone Biotechnology Co., Ltd. It concentrates more than
15-years research and knowledge from Gendone and Chinese agricultural scientists and has been
widely accepted and used by local & foreign customers for more than 10 years.
As the exclusive precursor of creatine, guanidinoacetic acid was authorized by China, Europe and
USA as a new feed additive, and it has been widely proved with significant improvements in growth
performance, carcass traits, laying and hatching performance for poultry.
Guanidinoacetic acid (GAA) is the direct endogenous precursor of creatine in the organism of all vertebrates.
Creatine biosynthesis is a two-step process. In the kidney, arginine transfers its amidino group to glycine to
synthesize GAA. GAA is transferred to the liver, where S-adenosylmethionine (SAM) gives its methyl group to
GAA to synthesize creatine. Creatine is then transported by the bloodstream to the target cells with high energy
need, such as skeletal muscle, heart, brain, sperm and immune cells. Creatine plays a key role in energy transfer
and supply via creatine-phosphocreatine system. Dietary supplemental NutriBuilder? can increase creatine level
in the body by 20%.
1 2 3 4
Cr
CRT
ATP ATP ATP ATP
ATPase
ANT
ADP
PCr
ADP ADP
OP
ADP
ANT
mt
CK G CK-g CK-c CK-a
Comparison of hygienic indexes among different brands
Comparison of body condition after using different brands of GAA
Item
GAA(%)
Cyanamide(mg/kg)
Dicyandiamide(mg/kg)
Melamine(mg/kg)
Dioxin(pg TEQ/kg)
≥96%
≤100
≤500
≤2.5
≤100
≥96%
≤300
≤5000
≤20
≤750
＜96%（variable）
2000-20000
2000-10000
20-200
1000-5000
NutriBuilder? Overseas brand Local brand
① Cyanamide, 300 mg/kg in GAA will cause weight loss, anemia, hypothyroidism, stooping back, tremors,
rough fur, pale soft exudative (PSE) meat, nervous disorder and higher death rate.
② Dicyandiamide, 2000 mg/kg in GAA degrades into gaseous cyanide access to stomach acid, causes and
aggravates respiratory diseases.
③ Melamine, above 10 mg/kg in GAA reduces feed consumption, weight loss, bladder stones, crystalluria,
renal failure and reduces survival rate.
④ Dioxins, above 750 pg TEQ/kg in GAA are extremely harmful to human and animals. Human will suffer
reproductive function damage and development problems, immune system damage and cancer after
eating even low level of dioxins.
2 High content of GAA, strict quality control for residues.
With a near density (550 kg/m3±10%) as corn and soybean, it can be easily premixed well
with feedstuff.
3
Inferior GAA NutriBuilder?
Laying performance in AA﹢broiler breeders from 46 to 50 weeks
Energy sparing effect in broiler
For breeder
Proper dose of GAA in breeder feed can enhance semen quality and sperm motility, improve the fertility and
hatchability by 5%-10% and reduce the mortality of embryos, increase growth performance of offspring.
Control Reduced 150 kcal Reduced 150 kcal+0.06% NutriBuilder?
2.72
Body weight gain(kg)
2.61
2.71
2.55
2.60
2.65
2.70
2.75
1.60
F:G
1.70
1.61
1.55
1.60
1.65
1.70
1.75
Control 0.08% GAA 0.12% NutriBuilder?
Control 0.08% GAA 0.12% NutriBuilder?
72.53
Laying rate(%)
78.15
50
55
60
65
70
75
80 77.82
63.60
Average egg weight(g)
63.52 63.55
50
52
54
56
58
60
62
64
66
2.3
Feed/egg
2.3 2.28
2.0
2.1
2.2
2.3
2.4
Hatching performance in AA+broiler breeders from 46 to 50 weeks
87.75
Qualified egg rate(%)
92.62
93.15
83
85
87
89
91
93
95
82.59
Fertilization rate(%)
93.50 94.03
76
80
84
88
92
96
76.32
Hatchability(%)
88.80 89.12
65
70
75
80
85
90
95
Beijing Gendone Biotechnology Co., Ltd.
Address: Room 601, Block B, Gem Techcenter, Shangdi 3rd St., Haidian Dist., Beijing, China
ZIP Code: 100085 TEL: +86-10-82890948
Email: overseadept@gendone.com
Gu an Gendone Biological Engineering Co., Ltd.
Address: Southern Dist., Industrial Park, Gu an County, Langfang City,
Hebei Province, China
ZIP Code: 065500 TEL: +86-10-82890948
http://www.gendone.com
Contact us
